Determination of Alkylamines and Alkylamides in Food Packaging Plastics by Liquid Chromatography High-Resolution Mass Spectrometry
10.19756/j.issn.0253-3820.241475
- VernacularTitle:液相色谱-高分辨质谱检测食品包装塑料中的烷基胺和烷基酰胺
- Author:
Ling LIU
1
;
Yi-Zhe ZHU
;
Rui-Fen ZHENG
;
Jun-Xian HE
;
Cai-Ming TANG
Author Information
1. 东莞理工学院,生态环境工程技术研发中心,东莞 523808
- Keywords:
Liquid chromatography high-resolution mass spectrometry;
Food packaging plastics;
Alkylamines;
Alkylamides
- From:
Chinese Journal of Analytical Chemistry
2025;53(7):1186-1195,中插26-中插38
- CountryChina
- Language:Chinese
-
Abstract:
An efficient analytical method was developed for simultaneous detection of alkylamines and alkylamides in food packaging plastics using liquid chromatography-high resolution mass spectrometry(LC-HRMS).Based on the physicochemical properties of alkylamines and alkylamides,as well as the complexity of plastic samples,sample pretreatment and chromatographic-mass spectrometric parameters were optimized.The samples were extracted by vortex-ultrasonic extraction with a methanol-acetonitrile mixture for 15 min,followed by nitrogen evaporation to concentrate the extract,reconstitution,and analysis.The chromatographic mobile phase consisted of 0.1%formic acid aqueous solution and acetonitrile,and a gradient elution was used.The electrospray ionization(ESI)source was operated in positive ion mode,and mass spectrometry data were collected in full scan and data-dependent acquisition modes.Quantification was performed using an isotope-labeled internal standard method.The results showed that within the quantification range of 1-1000 ng/mL,the calibration curves exhibited good linearity(R2>0.99).Some compounds interfered with the validation experiments at higher concentrations,so only 10 kinds of target analytes were validated.Using a mixed food packaging plastic matrix,the recoveries at spiking levels of 40,400,and 4000 ng/g were mostly between 66.0%and 117.1%,with relative standard deviations ranging from 0.6%to 10.6%.The method was applied to detect 14 food packaging plastic samples,and the results showed that the concentrations of alkylamines and alkylamides ranged from not detected to 8924 ng/g.This method offered high sensitivity and accuracy,and was suitable for the screening and quantitative determination of alkylamines and alkylamides in plastics.
