Electrochemical Sensor Based on Nitrogen-Doped Carbon Nanobowl-Modified Electrode for Nitrofurantoin Detection
10.19756/j.issn.0253-3820.251122
- VernacularTitle:基于氮掺杂碳纳米碗修饰电极的电化学传感器用于检测呋喃妥因
- Author:
Yao-Juan HU
1
;
Rui-Ying GUO
;
Hui-Ru TANG
;
Hui-Lin LI
;
Feng-Yun HE
;
Chang-Li ZHANG
;
Chang-Yun CHEN
Author Information
1. 南京晓庄学院环境科学学院,南京 211171
- Keywords:
Nitrofurantoin;
Nitrogen-doped carbon nanobowl;
Electrochemical sensor
- From:
Chinese Journal of Analytical Chemistry
2025;53(7):1127-1137
- CountryChina
- Language:Chinese
-
Abstract:
Nitrofurantoin(NFT)is a nitrofuran antibiotic commonly used as a veterinary drug to treat bacterial infections in animals.However,due to the low solubility and bioaccumulation properties,NFT is prone to leave excessive residues in animal-derived foods and water systems,posing serious threats to human health and ecosystems.Therefore,there is an urgent need to develop an efficient and rapid detection method for NFT.In this work,nitrogen-doped carbon nanomaterials with unique bowl-like structures(N-CNBs)were synthesized via a hydrothermal-carbonization method.The morphology,surface structure,and specific surface area of N-CNBs were characterized using transmission electron microscopy(TEM),scanning electron microscopy(SEM),and X-ray photoelectron spectroscopy(XPS).The N-CNB modified glassy carbon electrode(N-CNB/GCE)was prepared,and the electrochemical test revealed that the N-CNB/GCE exhibited higher conductivity and larger electrochemical active surface area compared to bare GCE and nitrogen-doped hollow carbon nanosphere-modified electrode(N-HCNS/GCE).Additionally,the N-CNB/GCE demonstrated superior electrocatalytic activity toward NFT.An NFT electrochemical sensor was constructed based on N-CNB/GCE.The detection conditions of the sensor were optimized,and differential pulse voltammetry(DPV)was employed for NFT detection under optimal experimental conditions.The established NFT electrochemical sensor had a wide linear range of 0.4-500 μmol/L,a low detection limit(S/N=3)of 0.015 μmol/L and high selectivity,with excellent stability and reproducibility.The practical feasibility of this sensor was confirmed by analysis of NFT in milk and tap water samples,with spiked recoveries ranging from 94.2%to 108.9%.
