Advancements in Exosomal Protein Detection Methods and Their Applications in Tumor Diagnosis
10.19756/j.issn.0253-3820.251061
- VernacularTitle:外泌体蛋白检测方法的研究进展及其在肿瘤诊断中的应用
- Author:
Hao-Cheng CHANG
1
;
Ting-Hui WEN
;
Hui-Xia DI
;
Xiao-Chun LI
Author Information
1. 太原理工大学人工智能学院,生物医学精准检测与仪器研究所,晋中 030600
- Keywords:
Exosomal protein;
Biomarker;
Liquid biopsy;
Detection methods;
Tumor diagnosis;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(7):1037-1049
- CountryChina
- Language:Chinese
-
Abstract:
Early screening of tumors is crucial for prevention and treatment of cancer,thus identifying effective biomarkers is of great importance for early diagnosis of tumors.In recent years,tumor-secreted exosomes(Exos)have attracted widespread attention as a novel biomarker for tumor liquid biopsy.Especially,some specific proteins contained in Exos play important roles in the occurrence,development,metastasis and microenvironment regulation of tumors,indicating their enormous potential as potential diagnostic biomarkers for tumors.Compared to traditional biopsy sample testing,exosome-based protein detection methods exhibit significant advantages in liquid biopsy,including rapid sampling,easy operation,non-invasiveness,and feasibility for early detection,holding important application value for clinical diagnosis of tumors.This review aimed to comprehensively summarize and discuss various detection strategies for exosomal proteins in liquid biopsy for tumors,while comprehensively evaluating the analytical performance of these methods.Meanwhile,new perspectives and strategies for early diagnosis and treatment of tumors were discussed.Additionally,the unique advantages of exosomal proteins as a new generation of non-invasive diagnostic biomarkers and insights into their promising prospects for future clinical applications were emphasized.
