Construction and Application of"On-Off-On"Fluorescence Sensor for Chlorpromazine Hydrochloride Based on Near Infrared Carbon Quantum Dots
10.19756/j.issn.0253-3820.231189
- VernacularTitle:基于近红外碳点的"开-关-开"型盐酸氯丙嗪荧光传感器的构建
- Author:
Yu LIN
1
;
Feng TAN
;
Yu-Hua SHEN
;
Li-Qin ZHU
;
Pei-Yao YAN
;
Jin-Tao PAN
;
Kai-Shun LIU
Author Information
1. 广西中医药大学药学院,南宁 530001
- Keywords:
Near infrared carbon quantum dots;
Fluorescence sensor;
Palladium ion;
Chlorpromazine hydrochloride
- From:
Chinese Journal of Analytical Chemistry
2025;53(6):934-943
- CountryChina
- Language:Chinese
-
Abstract:
In this work,near infrared carbon quantum dots(NIR-CDs)were synthesized by hydrothermal method using biomass material Clausena lansium leaves.The synthesized NIR-CDs emitted maximum fluorescence signal at 677 nm,which was independent of excitation wavelength.The characterization results showed that there were abundant groups on the surface of NIR-CDs.Pd2+could form non-fluorescent compounds with the surface groups of NIR-CDs,resulting in fluorescence quenching(Fluorescence signal was denoted as F0).Because chlorpromazine hydrochloride(CPZ)parent nucleus contained unoxidized S atom,CPZ could form stable colored complex with Pd2+under acidic conditions.In the presence of CPZ,Pd2+dissociated from the surface of NIR-CDs and bonded with CPZ,so that the fluorescence signal could be restored(Fluorescence signal was denoted as F).An"on-off-on"fluorescence sensor was thus constructed.The fluorescence signal recovery value of NIR-CDs(△F=F-F0)showed a good linear relationship with the concentration of CPZ in the range of 5.68-28.43 μg/mL,and the detection limit(3σ)was 0.078 μg/mL.The sensor was applied to determination of CPZ in pharmaceutical preparations,and the recoveries were 94％-106％.The developed fluorescence sensor was expected to be used in quality control of actual pharmaceutical preparations.
