Improvement of Performance of Ion Mobility Spectrometry Using A Low Discrimination Bradbury-Nielsen Gate Controlling Method
10.19756/j.issn.0253-3820.251044
- VernacularTitle:提升离子迁移谱性能的低迁移率歧视Bradbury-Nielsen门控方法研究
- Author:
Qi-Mu YANG
1
;
Yi-Qian XU
;
Man-Man PAN
;
Dan-Dan JIANG
;
Chuang CHEN
;
Hai-Yang LI
Author Information
1. 中国科学院大连化学物理研究所,医学蛋白质组全国重点实验室,大连 116023;中国科学院大学,北京 100049;辽宁省质谱技术与仪器重点实验室,大连市在线谱学分析仪器重点实验室,大连 116023
- Keywords:
Ion mobility spectrometry;
Bradbury-Nielsen gate;
Ion mobility discrimination;
Temporal compression;
Ion converging effect
- From:
Chinese Journal of Analytical Chemistry
2025;53(6):875-884
- CountryChina
- Language:Chinese
-
Abstract:
The resolving power and sensitivity are critical for on-site detection of hazardous chemicals using stand-alone ion mobility spectrometry(IMS).However,improving the sensitivity and resolving power of IMS has long been a prominent research hot spot.In the commonly used IMS based on the Bradbury-Nielsen gate(BNG),the gating voltage difference(GVD)applied between the two sets of grid wires affects the electric field distribution in the ionization region and the drift region.This,in turn,influences the spatial distribution and temporal width of the injected ion swarm,and has an impact on the ion mobility discrimination,sensitivity,and resolving power of the instrument.This study showed that increasing the GVD could induce an ion converging effect,boosting the ion number density in front of the BNG by nearly 300％.To simultaneously utilize temporal compression and ion converging effects,a novel BNG controlling mode was proposed by adding a chopping state to the conventional controlling mode.This chopping state reduced the mobility discrimination effects between ions with mobility differences up to about 0.90 cm2/(V·s)to 1/22 of their original value.When analyzing hazardous chemical mixtures using the novel BNG controlling mode,compared with conventional mode,the signal intensity of low-mobility methyl salicylate ions(MS·O2)-increased by 18-fold while the resolving power maintained around 100,and the detection limit for MS was improved from 3.75 μg/L to 97 ng/L.This novel BNG controlling mode only added a potential wave to the low voltage wires,with no requirement of changing the structure of the drift tube,and was easy to apply to existing commercial instruments.
