Research Progress on Electrochemical Sensing Techniques for Detection of Telomerase Activity
10.19756/j.issn.0253-3820.241309
- VernacularTitle:电化学传感技术用于端粒酶活性检测的研究进展
- Author:
Hai-Tang YANG
1
;
Peng-Hua SHU
;
Wen-Lin LIU
;
Wen-Bo MA
;
Zi-Jun YANG
;
Zhi-Feng DENG
;
Xin-Yun ZHANG
;
Wei WEI
Author Information
1. 许昌学院食品与药学院,许昌 461000
- Keywords:
Chemical sensing;
Telomerase activity;
Detection;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(6):864-874
- CountryChina
- Language:Chinese
-
Abstract:
The telomere structure in the cell nucleus is crucial for maintaining the stability and functions of chromosomes.Telomerase is a ribonucleoprotein reverse transcriptase,which catalyzes the elongation of telomeres using its own RNA as a template,thereby counteracting the shortening of telomeres caused by chromosome replication and cell division.Due to its overexpression in over 85％of malignant tumor cells,telomerase has emerged as a highly promising biomarker and a novel target for cancer therapy.In recent years,given the importance of precise quantification of telomerase activity in guiding medical diagnosis and treatment strategies,researchers have developed various high-performance telomerase detection techniques.Among these,electrochemical biosensing technique has cause much attention due to its high sensitivity,operational convenience,rapid response,and ease of miniaturization.This paper focused on the latest advances in electrochemical sensing technique for detection of telomerase activity,aiming to provide inspiration for designing novel telomerase activity detection strategies by elucidating three unique properties of telomerase primer extension products.
