Analysis of Nitrofuran Metabolites in Meat by Solid-Phase Extraction of Porous Organic Polymer Combined with Liquid Chromatography-Tandem Mass Spectrometry
10.19756/j.issn.0253-3820.241306
- VernacularTitle:多孔聚合物固相萃取-液相色谱-串联质谱法测定肉类中的硝基呋喃代谢物
- Author:
Yao CHEN
1
;
Ying-Jiao DONG
;
Jia-Yi LI
;
Rui-Jie WANG
;
Zhi-Kai HONG
;
Guan-Hua WANG
Author Information
1. 华南农业大学兽医学院,广州 510642
- Keywords:
Porous organic polymer;
Solid-phase extraction;
Veterinary drug residues;
Nitrofuran metabolites;
Ultra-performance liquid chromatography/quadrupole time-of-flight-tandem mass spectrometry
- From:
Chinese Journal of Analytical Chemistry
2025;53(5):804-813
- CountryChina
- Language:Chinese
-
Abstract:
In this work,with tris(4-aminophenyl)amine(TAPA)and 1,3,5-tris(4-formylphenyl)benzene(TFPB)as monomers,an imine-type porous organic polymer,TAPA-TFPB,was synthesized using a simple method under the catalysis of acetic acid.The material TAPA-TFPB was used as solid-phase extraction adsorbent and combined with ultra-performance liquid chromatography/quadrupole time-of-flight-tandem mass spectrometry(UHPLC-QTOF-MS)to establish a detection method for four kinds of nitrofuran metabolites(NFMs)residues in meat samples.The parameters of the adsorbent dosage,the pH value and volume of sample,and the type and volume of washing and eluent solvents were optimized,respectively.Under the optimal extraction conditions,low detection limits(0.11-1.60 μg/kg)were achieved for four kinds of NFMs.At three different spiked levels,the intra-day and inter-day precisions(Relative standard deviations)were 2.8% -10.9% and 4.3% -16.2%,respectively,and the spiked recoveries were 72.0% -107.2%.The results showed that the method chould be used for efficient extraction and analysis of trace NFMs residues in meat samples,indicating that TAPA-TFPB was a kind of promising SPE adsorbent.
