Ion Filtering and Reactivity Investigation Based on Tandem Ion Mobility Spectrometry
10.19756/j.issn.0253-3820.251043
- VernacularTitle:基于串级离子迁移谱的离子筛选及反应性研究
- Author:
Yi-Qian XU
1
;
Qi-Mu YANG
;
Man-Man PAN
;
Dan-Dan JIANG
;
Chuang CHEN
;
Hai-Yang LI
Author Information
1. 中国科学院大连化学物理研究所,医学蛋白质组全国重点实验室,大连 116023;中国科学院大学,北京 100049;辽宁省质谱技术与仪器重点实验室,大连市在线谱学分析仪器重点实验室,大连 116023
- Keywords:
Ion mobility spectrometry;
Photoionization;
Ion filtering;
Ion reactivity
- From:
Chinese Journal of Analytical Chemistry
2025;53(5):740-748
- CountryChina
- Language:Chinese
-
Abstract:
In analytical techniques such as ion mobility spectrometry(IMS)and mass spectrometry(MS),the ionization efficiency of target analytes is primarily constrained by the type of ionization source and factors such as the species and number density of the reactant ions.Systematic investigation into the reactivity differences of various reactant ions under varying conditions can not only significantly enhance the detection sensitivity of target compound product ions but also provide a theoretical foundation for establishing efficient detection methods based on ion-molecule reaction mechanisms.In this study,the pressure of a pressure-tunable photoionization tandem ion mobility spectrometry(PI-tandem-IMS)was reduced from ambient pressure(100 kPa)to low pressure(20 kPa)to systematically examine the reactivity differences between two negative reactant ions,CO3-and CO4-,and methyl salicylate(MeSA)under varying pressures.When the pressure decreased,the increased relative signal intensity of CO4-significantly influenced the detection sensitivity of the characteristic product ion[MeSA·O2]-.Based on differences in ion mobility(k0),the delay time for the opening of TPG2 was adjusted to selectively inject CO-3 and CO-4 in the drift region 2.Independent characterization of the reactivity of these reactant ions with MeSA in the reaction region confirmed that CO4-exhibited superior reactivity toward MeSA.The theoretical model revealed an Arrhenius plot for the ion-molecule reaction between CO4-and MeSA,showing a positive correlation between the reaction rate coefficient(k)and temperature,the activation energy Ea was 62.45 kJ/mol.Furthermore,controlling parameters such as pressure or temperature significantly influenced the progression of this ion-molecule reaction,demonstrating the technical advantages of PI-tandem-IMS in mechanistic studies and regulation of ion-molecule reactions.
