Research of Atmospheric Pressure Ion Heat Induced Dissociation Technology
10.19756/j.issn.0253-3820.241433
- VernacularTitle:常压离子热诱导解离技术的研究
- Author:
Tian-Xin XIAN
1
;
Tian-Yi ZHAO
;
Sen TIAN
;
Yun-Jing ZHANG
;
Xing-Li HE
;
Peng LI
;
Ling-Feng LI
Author Information
1. 苏州大学电子信息学院,苏州 215006
- Keywords:
Ambient heat-induced ion dissociation;
Drug;
Mass spectrometry;
Fragmention ion
- From:
Chinese Journal of Analytical Chemistry
2025;53(4):568-578
- CountryChina
- Language:Chinese
-
Abstract:
In the field of substance detection,ion dissociation techniques have become crucial for enhancing qualitative accuracy.By applying external energy to induce dissociation of ions in the substance being analyzed,the internal structural information can be obtained,thereby improving qualitative capabilities.Current research on ion dissociation techniques primarily focuses on tandem mass spectrometry,which typically requires a vacuum environment.However,research on ambient ion dissociation techniques is less developed,with some progress made in the field of tandem ion mobility spectrometry.Recently,the development of field-induced dissociation(FID)in this area has enabled ambient dissociation of various explosive and volatile alcohol ions.Nevertheless,the limitation imposed by the maximum breakdown field of air restricts the energy of the electric field,making it challenging to dissociate ions with high energy requirements,such as those of drugs.To address this issue,in this work,an ambient heat-induced dissociation(HID)technique based on high temperatures was proposed,in which an ambient ion heat-induced dissociation unit was developed and integrated into a home-made ion trap mass spectrometer.Experiments were conducted on four representative drug samples,e.g.methamphetamine,heroin,cocaine,and ketamine.The parent ions mass spectra,low vacuum collision-induced dissociation(CID)mass spectra and ambient HID mass spectra for each sample were obtained.By analyzing and comparing the fragmentation products from ambient and low vacuum dissociation,the feasibility of the ambient HID technique was verified.This technique provided a method for ion dissociation in single mass analyzers without tandem mass spectrometry capability and offered a new research direction for the future development of tandem ion mobility spectrometry.
