Research Progress on Detection of Illicit Drug in Biological Samples Based on Surface-Enhanced Raman Spectroscopy
10.19756/j.issn.0253-3820.251034
- VernacularTitle:基于表面增强拉曼光谱的生物样品中毒品检测研究进展
- Author:
Min LI
1
;
Ji ZHOU
;
Jian SUN
Author Information
1. 新疆医科大学药学院,新疆生物药械重点实验室,乌鲁木齐 830017;新疆警察学院,乌鲁木齐 830011
- Keywords:
Surface-enhanced Raman spectroscopy;
Biological samples;
Illicit drug;
Technology integration;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(4):505-515
- CountryChina
- Language:Chinese
-
Abstract:
One of the key elements in effectively combating drug crimes is identification and management of drug users.Developing efficient and rapid detection methods for drugs and their metabolites in biological samples such as blood,urine,and hair are crucial for the screening and identification of potential drug users.Since most of the parent drugs are metabolized after entering the body,challenges such as reduced residue levels,numerous metabolites,and complex biological sample matrices arise,posing higher requirements on the specificity and sensitivity of detection technologies.Surface-enhanced Raman spectroscopy(SERS)offers advantages including fingerprint identification,high sensitivity,high accuracy,high selectivity,and non-destructiveness,enabling precise detection of trace amounts of drugs in complex biological samples.This paper reviewed the application progress of SERS technique in drug detection of biological samples,focusing on the selection and preparation of SERS enhancement substrates,detection methods,and the research advancements of SERS combined with other technologies.The detection capabilities and applicability of SERS in this field were summarized,and the challenges and development trends faced by SERS in detection of trace drugs in biological samples were discussed.
