Synthesis and Identification of Saturated Arsenic-containing Hydrocarbons
10.19756/j.issn.0253-3820.221585
- VernacularTitle:饱和含砷碳氢化合物的合成与鉴定
- Author:
Jia-Jia CHEN
1
;
Ying-Xiong ZHONG
;
Xin-Huang KANG
;
Chun-Mei DENG
;
Bing-Bing SONG
;
Xiao-Fei LIU
;
Zhuo WANG
;
Rui LI
;
Jian-Ping CHEN
;
Xue-Jing JIA
;
Sai-Yi ZHONG
Author Information
1. 广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋生物制品工程实验室,广东省海洋食品工程技术研究中心,湛江 524088
- Keywords:
Lipid-soluble arsenic compounds;
Synthesis;
Nuclear magnetic resonance;
High-resolution mass spectrometry
- From:
Chinese Journal of Analytical Chemistry
2025;53(3):472-480
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is a semi-metal,and lipid-soluble arsenic compounds are one of the widespread forms in the environment and food chain,but there is a lack of standards for lipid-soluble arsenic compounds,which is one of the bottlenecks in the current analytical detection and toxicological studies of organic arsenic.In this study,four saturated arsenic-containing hydrocarbons,AsHC 318,AsHC 332,AsHC 346,and AsHC 374(The number is relative molecular mass),were successfully synthesized in three steps by using dimethylarsinic acid,potassium iodide,sodium hydroxide,and four brominated alkanes(1-Bromotetradecane,1-bromopentadecane,1-bromohexadecane,and 1-bromooctadecane)as raw materials.The structures of these four saturated arsenic-containing hydrocarbons were characterized by proton nuclear magnetic resonance(1H NMR)spectroscopy,13C nuclear magnetic resonance(13C NMR)spectroscopy,and high-resolution mass spectrometry(HR-MS).The yields of the method were 8%-10%,and the synthesized compounds could be used in subsequent toxicity evaluation experiments to assess the toxic effects and mechanisms of action of arsenic-containing hydrocarbons.This study provided an effective method for synthesis of arsenic-containing hydrocarbons,enriching the synthesis methods of arsenic-containing hydrocarbons,and provided raw materials for the subsequent toxicological studies of arsenic-containing hydrocarbons.
