Research Progress on Detection Methods for Cytokeratin 19 Fragment Antigen 21-1
10.19756/j.issn.0253-3820.241369
- VernacularTitle:细胞角蛋白19片段抗原21-1检测方法的研究进展
- Author:
Jia-Hui DONG
1
;
Li-Yue SHEN
;
Ji-Hao SI
;
Xiao-Ping YU
;
Tao PENG
Author Information
1. 中国计量大学生命科学学院,杭州 310018;中国计量科学研究院前沿计量科学中心,北京 100029;国家市场监督管理总局技术创新中心(质谱),北京 100029
- Keywords:
Cytokeratin 19 fragment antigen 21-1;
Tumor markers;
Detection methods;
Lung cancer;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(3):328-337
- CountryChina
- Language:Chinese
-
Abstract:
Cytokeratin 19 fragment antigen 21-1(CYFRA21-1)is a new biomarker which has received much attention in recent years for cancer screening,and has shown great potentials for screening and diagnosis of various cancers,especially non-small cell lung cancer.CYFRA21-1 level in human serum has important clinical significance in the diagnosis,prognosis and treatment of lung cancer.Recently,a variety of detection techniques have been established to effectively enrich the detection technology system of CYFRA21-1,such as enzyme-linked immunosorbent assay,chemiluminescence,fluorescence,immunochromatography,electrochemical method,and surface enhanced Raman spectroscopy,etc.These techniques provide technical support for early diagnosis of lung cancer.However,the research progress of CYFRA21-1 detection methods is rarely reported.In this paper,CYFRA21-1 and its clinical significance were briefly introduced,and the progress of detection technology in recent ten years was reviewed,which was expected to provide reference for developing more sensitive,accurate,fast and convenient detection methods.
