In Vivo Electrochemical Analysis of Brain Neurochemistry:Opportunities and Challenges in Clinical Applications
10.19756/j.issn.0253-3820.251000
- VernacularTitle:脑神经活体原位电化学分析在临床应用中的机遇与挑战
- Author:
Ke LI
1
;
Huan WEI
;
Ran LIU
;
Yi-Fei XUE
;
Li-Juan LI
;
Li-Juan HOU
;
Lan-Qun MAO
Author Information
1. 北京师范大学体育与运动学院,北京 100875
- Keywords:
In vivo electrochemistry;
Clinical application;
Fast scan cyclic voltammetry;
Brain neurochemistry;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(3):311-327
- CountryChina
- Language:Chinese
-
Abstract:
Neuroscience,a cutting-edge field in interdisciplinary research,consistently draws considerable research interest,of which quantitatively probing the neurochemical dynamics is essential for brain science research.In vivoelectrochemical analysis,featuring with high sensitivity,high spatiotemporal resolution,free from transfection,and designable electrode/solution interfaces,provides important tools for in vivo neurochemicals sensing.Fast scan cyclic voltammetry combined with microelectrodes can not only enable precise detection of dopamine but also is compatible with existing neurosurgical equipment.This offers new opportunities for the clinical application of in vivo electrochemical analysis and paves new avenues for the diagnosis and treatment of neurological diseases.This review summarized recent progress of in vivo electrochemical techniques for brain neurochemistry and addressed key clinical challenges and their potential solutions.
