Gas Chromatography-Infrared Spectroscopy Assisted Gas Chromatography-Mass Spectrometry for Identification of Alkyl Phosphonate Isomers
10.19756/j.issn.0253-3820.241045
- VernacularTitle:气相色谱-红外光谱辅助气相色谱-质谱鉴定烷基膦酸酯类化合物同分异构体
- Author:
Mei-Qi ZHAO
1
;
Yu-Long LIU
;
Qin LIU
;
Wei YOU
;
Jian-Feng WU
;
Hai-Xia WU
;
Jia CHEN
;
Jian-Wei XIE
Author Information
1. 军事医学研究院毒物分析实验室,北京 100850;河北科技大学化学与制药工程学院,石家庄 050091
- Keywords:
Alkyl phosphonate;
Isomers;
Gas chromatography-infrared spectroscopy;
Gas chromatography-mass spectrometry;
Nerve agents;
Structural identification
- From:
Chinese Journal of Analytical Chemistry
2025;53(2):269-277
- CountryChina
- Language:Chinese
-
Abstract:
Organophosphorus nerve agents are the most threatening chemical warfare agents and terrorist agents.The number of nerve agents and their related chemicals involved in the verification of Chemical Weapon Convention(CWC)exceeds ten million,with the majority being isomers.Accurate structural identification of these chemicals has always been one of the challenges in CWC related verification analysis.In this work,a total of 17 kinds of alkyl phosphonate isomers and structural analogs from 5 groups were designed and synthesized,and then analyzed by gas chromatography-mass spectrometry(GC-MS)and gas chromatography-infrared spectroscopy(GC-FTIR).The spectra of isomers or structural analogs obtained from two techniques as well as the structural information provided therein were compared and analyzed.The results showed that for isomers or structural analogs with similar MS spectra,FTIR spectra could provided more structural fingerprint information of compounds and had advantages in confirming structures.Combined with the excellent separation ability of GC,GC-FTIR can be used to assist GC-MS in the structural confirmation of alkyl phosphates,achieving rapid and accurate identification of isomers or structural analogues.
