Synthesis and Application of Salicylhydrazone Probe for Highly Selective Detection of Al3+
10.19756/j.issn.0253-3820.241440
- VernacularTitle:水杨酰腙型高选择性铝离子荧光探针的合成及其应用研究
- Author:
Hao-Xue TAN
1
;
Zhong-Long WANG
;
Xiao-Qin YANG
;
Xiao-Ping RAO
;
Ping ZHAO
;
Qian JIANG
Author Information
1. 西南林业大学,西南地区林业生物质资源高效利用国家林业和草原局重点实验室,昆明 650224
- Keywords:
Fluorescence probe;
Salicylhydrazone compounds;
Aluminium ion;
Recognition;
Cell imaging
- From:
Chinese Journal of Analytical Chemistry
2025;53(2):214-223,中插3-中插12
- CountryChina
- Language:Chinese
-
Abstract:
In this work,four salicylhydrazone compounds(L1?L4)were designed and synthesized by using vanillin derivatives as raw material.The structures were confirmed by nuclear magnetic resonance(NMR)and high-resolution mass spectrometry(HRMS).The optical experiments showed that probe L1 and probe L3 could be used as aluminium ion(Al3+)fluorescence probes.The fluorescence color of probe L1 solution changed from colorless to blue after adding Al3+,and the limit of detection was 25.1 nmol/L.Compared with probe L1,the fluorescence color of probe L3 solution changed from colorless to green after complexing with Al3+,and the limit of detection was 17.3 nmol/L.Probe L1 and probe L3 showed the advantages of fast response speed,high selectivity and good anti-interference.The mechanism of Al3+recognition was further demonstrated by HRMS and 1H NMR.Cell imaging experiments showed that probe L1 and L3 had low cytotoxicity and had great application potential in detection of Al3+in vivo.
