Research Progress of Molecular Probes Driven by Tumor Boundary Imaging
10.19756/j.issn.0253-3820.241434
- VernacularTitle:肿瘤边界成像驱动的分子探针研究进展
- Author:
Wen-Zhi REN
1
;
Juan LI
;
Jun-Lie YAO
;
Jie XING
;
Hong-Ying BAO
;
Li SUN
;
Ai-Guo WU
Author Information
1. 中国科学院宁波材料技术与工程研究所,宁波市生物医学成像探针材料与技术重点实验室,中国科学院磁性材料与器件重点实验室,宁波 315201;宁波慈溪生物医学工程研究所,浙江省生物医学材料技术与应用国际合作基地,浙江省医用植介入材料工程研究中心,慈溪 315300
- Keywords:
Boundarics in biomedicine;
Biomedical boundarics;
Tumor boundary;
Molecular probes;
Magnetic imaging;
Optical imaging;
Acoustic imaging;
Nuclear imaging;
Review
- From:
Chinese Journal of Analytical Chemistry
2025;53(1):14-26
- CountryChina
- Language:Chinese
-
Abstract:
″Boundarics in biomedicine″(or″Biomedical boundarics″)is an emerging frontier interdisciplinary subject that focuses on addressing key scientific issues related to the formation,identification,and evolution of biological boundaries within living organisms.In this field,the study of tumor boundaries is of particular importance.Imaging tumor boundaries not only helps to reveal the molecular mechanisms of tumor boundary evolution and interaction with the microenvironment,tumor invasion and metastasis,but is also crucial for clinical tumor diagnosis,treatment decision-making,efficacy monitoring and prognosis evaluation.Molecular probes,as functional substances that enhance imaging signals,play a crucial role in tumor boundary recognition.In this article,the basic concepts and research significance of boundarics in biomedicine and tumor boundarics in biomedicine were summarized firstly.Then a comprehensive review of the research progress in tumor boundary imaging molecular probes was provided,covering areas such as magnetic imaging,optical imaging,acoustic imaging,nuclear imaging,and multimodal imaging.The strategies to regulate the sensitivity,specificity,and safety of molecular probes through chemical structure modifications,conjugation with targeting ligands,and tumor microenvironment-responsive designs were emphasized.Finally,the research trends of molecular probes for tumor boundary imaging were analyzed,and the challenges faced in this field and the future research directions were discussed.
