Recent Advances in Inorganic Sonosensitizers for Tumor Diagnosis and Treatment
10.19756/j.issn.0253-3820.241130
- VernacularTitle:无机声敏剂在肿瘤治疗和诊断中的研究进展
- Author:
Xin-Jing LIU
1
;
Ruo-Hao ZHANG
;
Xin-Yu FU
;
Jing FENG
;
Hong-Jie ZHANG
Author Information
1. 中国科学院长春应用化学研究所,稀土资源利用国家重点实验室,长春 130022;中国科学技术大学应用化学与工程学院,合肥 230026
- Keywords:
Inorganic sonosensitizers;
Sonodynamic therapy;
Imaging diagnosis;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(12):1785-1796
- CountryChina
- Language:Chinese
-
Abstract:
Sonodynamic therapy(SDT)is an emerging approach of cancer treatment that stimulates sonosensitizers by ultrasound to produce reactive oxygen species(ROS)and induce cancer cell death.Compared with organic sonosensitizers,inorganic sonosensitizers have many advantages in stability,toxicity,water solubility,tumor targeting and functional regulation,showing extensive potentials in diagnosis and treatment of tumors.Thanks to the excellent properties,numerous sonosensitizers based on inorganic nanomaterials have been reported,mainly including titanium-based sonosensitizers,other metal-based sonosensitizers and non-metal-based sonosensitizers,and their prospects in diagnosis and treatment of tumor have been discussed.This review introduced the mechanism of SDT,overviewed the research progress of different systems of inorganic sonosensitizers in treatment and diagnosis of tumor,and summarized the methods to improve the therapeutic effect of SDT.Finally,the existing problems and development perspective of inorganic sonosensitizers were discussed and prospected.
