Study on the correlation between CXCR1 expression and neutrophil infiltration in chronic rhinosinusitis
10.16066/j.1672-7002.2025.08.004
- VernacularTitle:慢性鼻窦炎中CXC趋化因子受体1的表达与中性粒细胞浸润的相关性研究
- Author:
Qing HAO
1
;
Zhaonan XU
;
Shuang TENG
;
Bingrui YAN
;
Shuo LIU
;
Yanan SUN
Author Information
1. 哈尔滨医科大学附属第二医院耳鼻咽喉头颈外科,黑龙江 哈尔滨 150081
- Keywords:
Sinusitis;
Nasal Polyps;
Neutrophils;
Receptors,CXCR;
chemokine receptor 1
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2025;32(8):492-495,524
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the differential expression of CXC chemokine receptor 1(CXCR1)in chronic rhinosinusitis(CRS)and its correlation with neutrophil infiltration.METHODS A total of 60 CRS patients with nasal polyps(CRSwNP group),30 CRS patients without nasal polyps(CRSsNP group),and 30 patients with deviated nasal septum(control group)were enrolled in this study.ELISA,immunohistochemistry,and reverse transcription polymerase chain reaction were employed to measure CXCR1 expression levels.Correlation analysis was conducted to evaluate the relationship between CXCR1 expression,neutrophil infiltration,and clinical symptom scores.RESULTS CXCR1 was highly expressed in both tissues and serum of CRSwNP patients.Serum CXCR1 levels showed positive correlations with peripheral blood neutrophil counts(r=0.363,P=0.004 4),neutrophil percentage(r=0.323,P=0.011 7),visual analog scale(VAS)score(r=0.328,P=0.010 5),Lund-Kennedy endoscopic score(r=0.331,P=0.009 9),and Lund-Mackay CT score(r=0.262,P=0.045 0).Tissue CXCR1 levels were positively correlated with tissue neutrophil counts(r=0.506,P=0.011 6)and percentage(r=0.564,P=0.004 1).CONCLUSION CXCR1 is highly expressed in CRSwNP patients,and its expression level is positively correlated with the degree of neutrophil infiltration and clinical symptom scores.Higher CXCR1 levels are associated with increased neutrophil migration in both serum and tissues,as well as more severe clinical symptoms.
