Association study of pediatric obstructive sleep apnea hypopnea syndrome and otitis media with effusion based on clinical prediction model and Mendelian randomization
10.16066/j.1672-7002.2025.06.009
- VernacularTitle:基于临床预测模型的儿童阻塞性睡眠呼吸暂停低通气综合征与分泌性中耳炎相关性研究
- Author:
Yahui ZHAO
1
;
Jianzhou GUO
;
Wei CHANG
;
Zhaofeng QIU
;
Yu LIU
Author Information
1. 长治医学院附属和平医院耳鼻咽喉科,山西 长治 046000
- Keywords:
Child;
Sleep Apnea,Obstructive;
otitis media with effusion;
predictive model;
Mendelian randomization
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2025;32(6):381-385
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the correlation between childhood obstructive sleep apnea hypopnea syndrome and otitis media with effusion,to provide evidence-based basis for clinical diagnosis and treatment.METHODS A total of 985 children were diagnosed in the Department of Otolaryngology,Heping Hospital Affiliated to Changzhi Medical College from September 2019 to March 2025.Combined or no OME patients for multivariate logistics regression analysis and construct related risk prediction model,obtain data of OSAHS(exposure factors)and OME(outcome)from the public database of genome-wide association studies(GWAS),two-sample Mendelian randomization(MR)analysis.RESULTS The risk prediction model for OME in children with OSAHS,Hosmer-Lemeshow goodness of fit test(χ2=12.541,P=0.157),C index of 0.749,Calibration calibration curve fitting,and correlation between children OSHAS and OME.Furthermore,the MR analysis using inverse variance weighting observed a positive causal relationship between OSAHS and OME in children(OR=1.05,95%CI=0.999-1.051,P=0.005).MR Egger test results(Q=42.358,P=0.716)and IVW(Q=43.271,P=0.759)showed no heterogeneity in the analysis,MR Egger intercept(intercept=-0.004,P=0.921)showed no horizontal pleiotropy,and the MR analysis results were stable.CONCLUSION There is a correlation between pediatric OSAHS and OME,and it increases the risk of OME.
