The predictive value of advanced lung cancer inflammation index for postoperative pharyngocutaneous fistula,recurrence,metastasis,and prognosis in laryngeal squamous cell carcinoma
10.16066/j.1672-7002.2025.06.002
- VernacularTitle:晚期肺癌炎症指数对喉鳞状细胞癌术后咽瘘、复发转移及预后的预测价值研究
- Author:
Pan CHENG
1
;
Ruixiang CEN
;
Dan LIU
;
Wei CAO
Author Information
1. 黄石市中心医院(湖北理工学院附属医院)医学检验科,湖北 黄石 435000;肿瘤分子诊断与治疗黄石市重点实验室,湖北 黄石 435000;肾脏疾病发生与干预湖北省重点实验室,湖北 黄石 435003
- Keywords:
Laryngeal Neoplasms;
Carcinoma,Squamous Cell;
Recidivism;
Prognosis;
advanced lung cancer inflammation index;
pharyngocutaneous fistula;
metastasis
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2025;32(6):348-353
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the predictive value of the advanced lung cancer inflammation index(ALI)for postoperative pharyngocutaneous fistula,recurrence,metastasis,and prognosis in patients with laryngeal squamous cell carcinoma(LSCC).METHODS This retrospective study analyzed the clinical data of 114 LSCC patients treated at Huangshi Central Hospital between January 2014 and December 2023.The data included tumor staging,ALI scores,age,gender,smoking history,alcohol history,diabetes,hypertension,hyperlipidemia,coronary heart disease,tumor differentiation,HPV infection,and tumor location.Based on the occurrence of pharyngocutaneous fistula,the patients were divided into the fistula group(10 cases)and the non-fistula group(104 cases).Single-factor and multi-factor logistic regression analyses were conducted to identify independent factors associated with postoperative pharyngocutaneous fistula.Patients were also classified into recurrence and metastasis groups(22 cases)and non-recurrence groups(92 cases),and further into poor prognosis(25 cases)and good prognosis groups(89 cases)based on follow-up results.Cox regression analysis was performed to identify factors influencing recurrence,metastasis,and prognosis.RESULTS Multivariate logistic regression analysis showed that tumor stage(stage Ⅰ-Ⅱ)[HR:0.040(95％CI:0.004-0.392)]and ALI score[HR:0.885(95％CI:0.805-0.972)]were independent protective factors for the occurrence of pharyngeal fistula(P<0.05).Multivariate Cox regression analysis further confirmed that tumor stage(stage Ⅰ-Ⅱ)[OR:0.180(95％CI:0.063-0.518)]and ALI score[OR:0.970(95％CI:0.939-0.992)]were independent protective factors for recurrence,metastasis,and poor prognosis(P<0.05).ROC curve analysis revealed that the AUC for ALI in predicting pharyngeal fistula was 0.910(95％CI:0.849-0.970),with a cutoffvalue of 29.877,sensitivity of 0.827,and specificity of 1.000.The AUC for ALI in predicting recurrence and metastasis was 0.804(95％CI:0.698-0.910),with a cutoffvalue of 34.398,sensitivity of 0.920,and specificity of 0.618.CONCLUSION The ALI score is an independent protective factor for the occurrence of postoperative pharyngocutaneous fistula,recurrence,metastasis,and poor prognosis in LSCC patients.It is a valuable predictor for early warning of postoperative complications,recurrence,metastasis,and prognosis,with potential clinical utility in guiding personalized treatment strategies.
