ESM-1 for risk prediction of OSA and its correlation with adhesion molecules
10.16066/j.1672-7002.2025.05.010
- VernacularTitle:内皮细胞特异性分子1对阻塞性睡眠呼吸暂停的风险预测及其与黏附分子的相关性研究
- Author:
Lichuan ZHANG
1
;
Jianhong WANG
;
Zhiting CHEN
;
Zhifu SUN
;
Yanjun FENG
;
Zhan YU
;
Haili SUN
Author Information
1. 首都医科大学附属北京安贞医院耳鼻咽喉头颈外科,北京 100029
- Keywords:
Sleep Apnea,Obstructive;
Risk;
Forecasting;
adhesion molecules;
endothelial dysfunction;
vascular injury;
ESM-1
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2025;32(5):323-328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE This study investigated the clinical implications of endothelial cell-specific molecule 1(ESM-1)in obstructive sleep apnea(OSA)patients,with particular focus on its dynamic correlation with adhesion molecules,aiming to elucidate the regulatory role of ESM-1 in OSA-associated vascular endothelial impairment.METHODS This cross-sectional study enrolled participants undergoing polysomnography(PSG)at the Sleep Medicine Center of Beijing Anzhen Hospital,Capital Medical University between March 2017 and January 2018.Based on the inclusion criteria,161 participants were ultimately included and divided into OSA group(n=118)and control group(n=43).Demographic data and polysomnography parameters were collected.We used a powerful high-throughput Multiplex Immunobead Assay technology to simultaneously test plasm cytokines levels of ESM-1,inter-cellular adhesion molecule 1(ICAM-1),vascular cell adhesion molecule 1(VCAM-1).Circulating C-reactive protein(CRP)and homocysteine(Hcy)were detected by routine blood chemistry panel.RESULTS Circulating ESM-1 levels were significantly elevated in patients with OSA compared with healthy controls[819.73(612.36-1393.47)pg/ml]vs.[286.17(114.48-513.81)pg/ml,P<0.001].After adjusting for confounding factors,we found that circulating ESM-1 levels were an independent risk factor for OSA(odds ratio=2.162,95%CI=1.522-3.072,P<0.001)and circulating ESM-1 levels were positively associated with ICAM-1 and VCAM-1 levels(β=1.977,95%CI=1.429-2.734,P<0.001).CONCLUSION Circulating ESM-1 levels were significantly increased in patients with OSA,which is closely related with adhesion molecules levels.ESM-1 may be a surrogate endothelial dysfunction marker and an independent risk factor for OSA.
