Proteomics comparison of nasal lavage fluid in chronic rhinosinusitis with nasal polyps with or without asthma
10.16066/j.1672-7002.2025.01.008
- VernacularTitle:伴或不伴哮喘的慢性鼻窦炎伴鼻息肉患者鼻腔灌洗液蛋白质组学分析
- Author:
Xianghuang LUO
1
;
Jing GUO
;
Yao YAO
;
Yujuan YANG
;
Jianwei WANG
;
Pengyi YU
;
Wenbin ZHANG
;
Yu ZHANG
;
Xicheng SONG
Author Information
1. 山东第二医科大学临床医学院,山东 潍坊 261000;青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科,山东省耳鼻喉疾病临床医学研究中心,烟台市耳鼻喉疾病重点实验室,山东 烟台 264000
- Keywords:
Sinusitis;
Nasal Polyps;
Asthma;
Proteomics
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2025;32(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Aimed to investigate the impact of comorbid asthma on chronic rhinosinusitis with nasal polyps(CRSwNP)and identify key proteins and signaling pathways.METHODS Proteomic methods were employed to analyze differentially expressed proteins(DEPs)in nasal lavage fluid(NLF)from control,CRSwNP,and CRSwNP with asthma groups.DIA quantitative analysis technology was used to assess the gradient changes of DEPs among the three groups to determine key proteins affected by comorbid asthma in CRSwNP.RESULTS Compared to the control group,1 377 and 1 006 DEPs were identified in the CRSwNP and CRSwNP with asthma groups,respectively.Peroxiredoxin-5(PRDX5),Ran-Binding Protein 1(RanBP1)(upregulated),and Keratin 9(KRT9)(downregulated)were identified as key proteins affecting CRSwNP with asthma.CONCLUSION Comorbid asthma may promote the occurrence and development of nasal polyps through specific key proteins and signaling pathways,providing new molecular insights into the interaction between CRSwNP and asthma.
