The role of TGF-β1,BMP-2 in patients with chronic rhinosinusitis with nasal polyps
10.16066/j.1672-7002.2024.12.008
- VernacularTitle:慢性鼻窦炎伴鼻息肉患者转化生长因子β1和骨形成蛋白2表达研究
- Author:
Yi XIAO
1
;
Yongxin WANG
;
Jialong CHEN
;
Jiying LIU
;
Xinhua LI
Author Information
1. 福建医科大学附属南平第一医院 耳鼻咽喉头颈外科,福建 南平 353000
- Keywords:
Transforming Growth Factor beta 1;
Sinusitis;
Osteitis;
bone morphogenetic protein-2;
tissue remodeling
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(12):785-789
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of transforming growth factor-beta 1(TGF-β1)and bone morphogenetic protein-2(BMP-2)in patients with chronic rhinosinusitis with nasal polyps(CRSwNP).METHODS A cohort of 44 CRSwNP patients and 32 control subjects was included in the study.The expression levels of TGF-β1 and BMP-2 proteins in the peripheral blood and nasal polyp tissues of CRSwNP patients were measured.The correlations with Lund-Mackay scores and global osteitis scoring scale(GOSS)scores were analyzed.RESULTS Compared to the control group,the peripheral blood level of TGF-β1 protein in CRSwNP patients was significantly reduced(t=2.650,P=0.009),while the expression difference of BMP-2 was not statistically significant.In the nasal polyp tissues,both TGF-β1(t=13.180,P<0.001)and BMP-2(t=8.699,P<0.001)protein expressions were decreased.TGF-β1 was most abundantly expressed in the glandular epithelium of the polyps,whereas BMP-2 showed higher expression in the mucosal epithelium.CONCLUSION The expression of TGF-β1 is downregulated in CRSwNP patients;an increase in BMP-2 may assist in the identification of refractory CRSwNP cases.
