Subjective sleep problems is associated with epigenetic age acceleration:a Mendelian randomization study
10.16016/j.2097-0927.202505006
- VernacularTitle:主观睡眠问题与表观遗传年龄加速关联的孟德尔随机化研究
- Author:
Xiaomei LI
1
;
Hao REN
;
Zheng ZHANG
;
Yimo SHEN
Author Information
1. 重庆市精神卫生中心精神六科
- Keywords:
sleep disorders;
epigenesis;
aging;
Mendelian randomization
- From:
Journal of Army Medical University
2025;47(19):2437-2444,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential causal associations between 3 common subjective sleep problems,daytime sleepiness,insomnia,and sleep apnea,and epigenetic age acceleration.Methods A two-sample Mendelian randomization(MR)study was conducted the publicly available genome-wide association study(GWAS)data to assess the causal effects of self-reported sleep problems on 4 indicators of epigenetic age acceleration,including intrinsic epigenetic age acceleration(IEAA),GrimAge acceleration,HannumAge acceleration,and PhenoAge acceleration.The primary analytical method was inverse-variance weighting(IVW),supplemented by sensitivity analyses using MR-Egger regression and the weighted median(WM)method to examine the robustness of the findings.Results IVW showed that daytime sleepiness was significantly positively associated with IEAA(β=1.83,95%CI:0.17～2.49,P=0.031)and HannumAge acceleration(β=1.81,95%CI:0.21～2.42,P=0.027),suggesting a potential accelerating effect on epigenetic aging.Insomnia also showed significant positive associations with IEAA(β=1.57,95%CI:0.40～2.73,P=0.009)and GrimAge acceleration(β=1.37,95%CI:0.18～2.56,P=0.024).No significant causal relationship was observed between sleep apnea and any indicator of epigenetic age acceleration(P>0.05).Conclusion Daytime sleepiness and insomnia may accelerate epigenetic aging,indicating their potential biological role in the aging process.The impact of sleep apnea remains unclear and warrants further investigation.
