Association between phthalates and high-density lipoprotein-related inflammatory indicators
10.16016/j.2097-0927.202506001
- VernacularTitle:邻苯二甲酸酯暴露与高密度脂蛋白相关炎症指标异常的关联性研究
- Author:
Yanzi ZHANG
1
;
Xiuling ZHU
;
Kai LI
;
Wenqian ZENG
;
Bing GUO
Author Information
1. 四川大学华西公共卫生学院/四川大学华西第四医院流行病与卫生统计学系
- Keywords:
phthalates;
high-density lipoprotein cholesterol;
novel inflammatory indicators
- From:
Journal of Army Medical University
2025;47(16):1940-1949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of urinary phthalate metabolites with 4 high-density lipoprotein-cholesterol(HDL-C)-related inflammatory indicators[lymphocyte/HDL-C ratio(LHR),monocyte/HDL-C ratio(MHR),neutrophil/HDL-C ratio(NHR),and platelet/HDL-C ratio(PHR)],and to explain their possible biological mechanisms.Methods The 4 573 adult participants from the National Health and Nutrition Examination Survey(NHANES)were subjected,and then generalized linear regression(GLM),restricted cubic spline(RCS),and weighted quantile sum(WQS)regressions were performed to explore the potential associations of phthalates mono-exposures and mixed exposures,respectively,with the HDL-C-related inflammation metrics.Results Nine urinary phthalate metabolites were significantly positively associated with at least 1 inflammatory marker,while 1 metabolite(MEP)showed a negative association with an inflammatory indicator(LHR).Some exposure metabolites showed a nonlinear association with outcome inflammatory indicators.WQS regression revealed varying weight contributions of individual metabolite to each inflammatory outcome.Subgroup analyses indicated differential association effects of phthalates with HDL-C-related inflammatory metrics across gender,age,and BMI populations.Conclusion There are associations between phthalate exposure and HDL-C-related inflammation indicators,but further studies are needed to reveal the underlying mechanisms.
