Pathogenesis of focal segmental glomerulosclerosis:from podocyte injury to precision therapy
10.16781/j.CN31-2187/R.20250228
- VernacularTitle:局灶节段性肾小球硬化发病机制研究:从足细胞损伤到精准治疗
- Author:
Zhou CHEN
1
;
Zhiyong GUO
Author Information
1. 海军军医大学(第二军医大学)第一附属医院肾内科,上海 200433
- Keywords:
focal segmental glomerulosclerosis;
podocyte injury;
pathogenesis;
precision medicine
- From:
Academic Journal of Naval Medical University
2025;46(10):1344-1349
- CountryChina
- Language:Chinese
-
Abstract:
Focal segmental glomerulosclerosis(FSGS)is a critical glomerular disease characterized by a complex pathogenesis involving podocyte injury,genetic variations,and immune dysregulation.Podocyte injury plays a central role in FSGS development,encompassing abnormalities in cytoskeletal structure and dynamics,dysfunction of cell adhesion,activation of programmed cell death pathways,and oxidative stress.In recent years,advancements in molecular biology and genomic technologies have deepened the understanding of FSGS pathogenesis,with notable progress in podocyte biology,genetics,and signaling pathway regulation.Genetic factors contribute significantly to FSGS,with studies on monogenic mutations,epigenetic regulatory mechanisms,and non-genetic mechanisms such as the circulating factor hypothesis and immune dysregulation enriching the molecular pathology of FSGS.Based on these mechanistic insights,researchers are exploring precision therapeutic targets,including podocyte-protective strategies,anti-fibrotic and anti-inflammatory approaches,and gene-and biomarker-guided therapies,to improve treatment outcomes.This review summarizes recent advances in the pathogenesis of FSGS,aiming to provide a theoretical framework and new insights for precision diagnosis and targeted therapy of this disease.
