Risk factors of postoperative infection and hemorrhage following ultrasound-guided percutaneous transhepatic biliary drainage for malignant obstructive jaundice
10.16781/j.CN31-2187/R.20250046
- VernacularTitle:超声引导下经皮经肝胆管穿刺置管引流术治疗恶性梗阻性黄疸术后感染、出血的危险因素分析
- Author:
Dongyu CHEN
1
;
Yiran LI
;
Yi QIAN
;
Dong JIANG
Author Information
1. 海军军医大学(第二军医大学)第三附属医院超声诊疗科,上海 200438
- Keywords:
percutaneous transhepatic biliary drainage;
malignant obstructive jaundice;
postoperative infection;
postoperative hemorrhage;
risk factors
- From:
Academic Journal of Naval Medical University
2025;46(10):1313-1321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causes of infection and hemorrhage in patients with malignant obstructive jaundice(MOJ)after ultrasound-guided percutaneous transhepatic biliary drainage(PTBD).Methods A total of 420 patients with MOJ after PTBD in The Third Affiliated Hospital of Naval Medical University from Jun.2023 to Sep.2024 were enrolled,and their condition after PTBD,medical histories,preoperative examinations,and other clinical data were retrospectively analyzed.Univariate and multivariate logistic regression analyses were performed to explore the risk factors for postoperative infection and hemorrhage,and receiver operating characteristic(ROC)curves were plotted.Results Univariate logistic regression analysis showed that ascites,diuretics use,repeated punctures,hepatitis B virus(HBV)DNA and preoperative hemoglobin(Hb)levels,and neutrophil count(NE)were associated with infection after PTBD(all P＜0.05).Multivariate logistic regression analysis showed that ascites,diuretic use,repeated punctures,HBV DNA and preoperative Hb levels,and NE were the independent risk factors for infection after PTBD(all P＜0.05).Six factors including ascites,diuretics use,repeated punctures,HBV DNA and preoperative Hb levels,and NE were used to establish a prediction model.The area under the ROC curve of the model for predicting infection after PTBD was 83.1％(95％confidence interval[CI]75.5％-90.7％,P＜0.001).Univariate logistic regression analysis showed that liver tissue inflammation,ascites,preoperative peritoneal drainage,diuretics use,preoperative Hb and prealbumin(PA)levels were related to bleeding after PTBD(all P＜0.05).Multivariate logistic regression analysis showed that preoperative Hb and PA levels were independent risk factors for bleeding after PTBD.Preoperative Hb and PA levels were included to establish the prediction model.The area under the curve value for predicting bleeding after PTBD was 86.3％(95％CI 80.8％-91.9％,P＜0.001).Conclusion The prediction model for infection and hemorrhage after PTBD can facilitate early preventivon and intervention measures,thereby improving surgical safety.
