Risk factors of cognitive disorder in middle-aged and elderly patients with Parkinson's disease:a retrospective case-control study
10.16781/j.CN31-2187/R.20240109
- VernacularTitle:中老年帕金森病患者认知障碍危险因素的回顾性病例对照研究
- Author:
Fanyuan MA
1
;
Weiming JIAN
;
Lijun AN
;
Liping WU
;
Hua ZHANG
Author Information
1. 空军军医大学唐都医院老年病科,西安 710038;中国人民解放军 94719 部队医院,吉安 343700;空军军医大学西京医院老年病科,西安 710032
- Keywords:
Parkinson's disease;
cognitive disorder;
type 2 diabetes mellitus;
uric acid;
risk factors
- From:
Academic Journal of Naval Medical University
2025;46(9):1169-1176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between type 2 diabetes mellitus(T2DM)and cognitive disorder in middle-aged and elderly patients with Parkinson's disease(PD),and to identify risk factors for cognitive disorder in PD patients.Methods The clinical data of patients aged≥50 years and hospitalized for PD in Xijing Hospital of Air Force Medical University from Jan.2010 to Dec.2021 were collected,including demographic characteristics,general clinical features,laboratory indicators,etc.The cognitive status was evaluated by mini-mental state examination(MMSE).A total of 281 PD patients were assigned to T2DM group or non-T2DM group,and MMSE original score,standardized score,and cognitive status were compared between the 2 groups.The 281 patients were reassigned to normal cognition group or abnormal cognition group,then multivariate logistic regression was used to analyze the risk factors of cognitive disorder in middle-aged and elderly patients with PD.Results The MMSE original score and standardized score in the T2DM group were significantly lower than those in the non-T2DM group(23[18,25]vs 24[21,27],P=0.011;-1[-3,2]vs 1[-1,3],P=0.004),and the detection rate of cognitive disorder was significantly higher than that of the non-T2DM group(53.57%[45/84]vs 33.50%[66/197],P=0.002).Multivariate logistic regression analysis showed that T2DM(odds ratio[OR]=2.452,95%confidence interval[95%CI]1.397-4.306,P=0.002),place of residence(OR=2.208,95%CI 1.261-3.868,P=0.006),and age(OR=1.054,95%CI 1.006-1.104,P=0.028)were risk factors for cognitive disorder in middle-aged and elderly patients with PD,while serum uric acid(OR=0.274,95%CI 0.098-0.768,P=0.014)was protective factor for cognitive disorder in middle-aged and elderly patients with PD.Conclusion T2DM,rural area,advanced age,and hypouricemia are independent risk factors for cognitive disorder in middle-aged and elderly patients with PD.For middle-aged and elderly PD patients with T2DM,screening for cognitive disorder should be strengthened for early prevention and intervention.
