Causal relationship among circadian rhythm disruption,gut microbiota,and inflammatory bowel disease:a Mendelian randomization study
10.16781/j.CN31-2187/R.20250282
- VernacularTitle:昼夜节律紊乱、肠道菌群和炎症性肠病之间的因果关系分析:一项孟德尔随机化研究
- Author:
Hongrong ZHU
1
;
Yueqi LENG
;
Jiacen SUN
;
Xing TAN
;
Weizhong WANG
Author Information
1. 海军军医大学(第二军医大学)海军特色医学中心,上海 200433
- Keywords:
circadian rhythm disruption;
gut microbiota;
inflammatory bowel disease;
Mendelian randomization
- From:
Academic Journal of Naval Medical University
2025;46(9):1138-1147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between circadian rhythm disruption and inflammatory bowel disease(IBD)and the mediating effect of gut microbiota based on Mendelian randomization(MR).Methods Summary statistics of Genome-wide Association Study(GWAS)for circadian rhythm disruption(n=205 527)and IBD(n=214 053)were obtained from IEU OpenGWAS database.Summary statistics of GWAS for the gut microbiota were obtained from the MiBioGen database(n=18 340).Two-sample MR analysis was used to estimate the genetic correlation and causality between circadian rhythm disruption and IBD,and the mediating effect of the gut microbiota was analyzed by two-step MR analysis.Results There was a suggestive causal relationship between circadian rhythm disruption and IBD(odds ratio=1.255,P＜0.05).Rikenellaceae id.967 played a mediating role in the causal chain between them(the mediating effect was-0.028 740).Sensitivity analysis confirmed that the results were not interfered by level pleiotropy and heterogeneity.Conclusion There is a genetic correlation between circadian rhythm disruption and IBD,and gut microbiota may play a mediating role between them.
