Androgens and androgen receptors in bronchial asthma:research progress
10.16781/j.CN31-2187/R.20240360
- VernacularTitle:雄激素及雄激素受体在支气管哮喘中的研究进展
- Author:
Yesong MENG
1
;
Ziqian XU
;
Haoran NI
;
Li LI
;
Yan SHANG
Author Information
1. 海军军医大学(第二军医大学)第一附属医院呼吸与危重症医学科,上海 200433
- Keywords:
androgen;
androgen receptor;
asthma;
immune cells
- From:
Academic Journal of Naval Medical University
2025;46(7):910-915
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma(hereinafter referred to as asthma)is a common chronic respiratory disease with significant gender differences.Epidemiologic surveys show that both the incidence and severity of asthma are significantly higher in adult females than in males.It is now believed that gender differences in asthma may be related to sex hormones,and the airway effects of estrogen and progesterone on asthma pathophysiology have been extensively studied.However,the mechanism of androgens in asthma is not clear.In recent years,some new studies have found that androgens and androgen receptors can exert anti-inflammatory effects in asthma through immune cells;moreover,they can also decrease airway hyperresponsiveness,relax airway smooth muscle,and improve lung function.This article reviews the progress of androgens and androgen receptors in asthma to deepen our understanding of the relationship between sex hormones and asthma,providing more options for future asthma treatment.
