Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3A protein in the evolution and development of cervical cancer:research progress

VernacularTitle:载脂蛋白B mRNA编辑酶催化多肽样3A蛋白在宫颈癌进化发育中的研究进展
Author: Haiwei HE ¹ ; Mingjuan XU
Author Information

1. 海军军医大学(第二军医大学)第一附属医院妇产科,上海 200433
Keywords: apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3A; uterine cervical neoplasms; evolution; development
From: Academic Journal of Naval Medical University 2025;46(6):798-802
CountryChina
Language:Chinese
Abstract: Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3A(APOBEC3A)mutation is a major driver of cervical cancer.APOBEC3A and human papilloma virus(HPV)is closely related.On the one hand,APOBEC3A can effectively inhibit HPV infection;on the other hand,it can promote the integration of HPV DNA into cervical keratinocytes.This paper reviews the complex interaction between HPV and APOBEC3A,and analyzes the involved viral mechanism and cellular signal pathway.A large number of studies have confirmed that APOBEC3A gene can effectively induce the evolution and development of a variety of malignant tumors,including cervical cancer.However,APOBEC3A protein level is not so high in cancer cells in clinic.This paper also discusses the significance and the potential therapeutic value of APOBEC3A activity in cervical cancer.