Pathogenesis and intervention strategies of abdominal aortic aneurysm:an update
10.16781/j.CN31-2187/R.20220360
- VernacularTitle:腹主动脉瘤的发病机制及干预策略研究进展
- Author:
Yue CHAI
1
;
Hongming SHAO
;
Wenbin WU
;
Ting HAN
;
Pei WANG
;
Chunlin ZHUANG
Author Information
1. 海军军医大学(第二军医大学)药学系,上海 200433
- Keywords:
abdominal aortic aneurysm;
pathogenesis;
intervention strategies;
inflammation
- From:
Academic Journal of Naval Medical University
2025;46(6):790-797
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysm(AAA)is a degenerative vascular disease occurring in the lower segment of the aortic diaphragm,mainly manifested by irreversible dilatation of the entire artery,preferably in the elderly population.The pathogenesis of AAA is complex and involves multiple factors,with genetic variations and immune imbalances playing important roles.Its pathological changes mainly include inflammatory cell infiltration,degradation of stromal elastin,and smooth muscle cell death.Rupture of AAA is the most dangerous complication,with a high mortality.Surgery remains the only effective intervention,but carries certain risks and postoperative complications.Early intervention for small abdominal aortic aneurysms to slow down aneurysm expansion and achieve long-term survival is currently a focus of drug and technology research.This article reviews the pathogenesis of AAA and its intervention strategies,and summarizes the research on existing drugs and the use of new targets and technologies,so as to provide insights for better understanding and treatment of AAA.
