Lipid metabolism modulates inflammatory response in Alzheimer's disease:research progress
10.16781/j.CN31-2187/R.20230595
- VernacularTitle:脂质代谢调控炎症反应参与阿尔茨海默病的研究进展
- Author:
Yike ZHANG
1
;
Chaofeng HAN
Author Information
1. 海军军医大学(第二军医大学)基础医学院组织胚胎学教研室,上海 200433
- Keywords:
lipid metabolism;
neuroinflammation;
microglia;
Alzheimer's disease
- From:
Academic Journal of Naval Medical University
2025;46(5):653-660
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease is a neurodegenerative disorder characterized by complex and not fully understood pathogenesis.Recent research has revealed that abnormalities in lipid metabolism and inflammatory responses play a crucial role in the development and progression of Alzheimer's disease.This review aims to explore the modulatory effects of lipid metabolism on inflammatory responses and their subsequent influence on the pathological processes of Alzheimer's disease from the aspects of the relationship between dysregulated lipid metabolism,increased inflammatory responses,and Alzheimer's disease,the regulatory effects of lipid mediators,and the role of microglia in these processes.
