Dietary regulation of intestinal stem cells:research progress
10.16781/j.CN31-2187/R.20240836
- VernacularTitle:饮食模式影响肠道干细胞功能的研究进展
- Author:
Xuede YAN
1
;
Dongmei CAO
;
Weiping ZHANG
Author Information
1. 海军军医大学(第二军医大学)基础医学院病理生理学教研室,上海 200433
- Keywords:
small intestine;
stem cells;
diet;
stem cell niche;
regeneration
- From:
Academic Journal of Naval Medical University
2025;46(5):559-566
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal stem cells(ISCs),locating at the base of intestinal crypts and pivotal in orchestrating the homeostasis and damage repair of the intestinal epithelium,are characterized by their self-renewal and multipotential differentiation capabilities.With the continuous discoveries of new ISCs and related markers,the ISC migration and regeneration model has been further improved,greatly promoting the research in related fields.Diet can regulate ISC glycolipid and energy metabolism through influencing the stem cell niche,subsequently modulating overall metabolism.This paper summarizes the biological features of both classical and newly discovered ISCs,and analyzes the effects of common nutrients and different dietary patterns on ISCs,hoping to provide insights for the precise nutrition prevention and treatment of chronic intestinal diseases.
