Emerging role of lysosomal regulation in Alzheimer's disease
10.16781/j.CN31-2187/R.20240479
- VernacularTitle:溶酶体调控在阿尔茨海默病中的新兴作用
- Author:
Mengqi HAO
1
;
Wenbo JI
;
Yuankai GU
;
Xinyu LU
;
Li WANG
;
Siqi LI
;
Along HOU
;
Chao GAO
;
You YIN
Author Information
1. 上海理工大学健康科学与工程学院,上海 200003;海军军医大学(第二军医大学)第二附属医院神经内科,上海 200003
- Keywords:
Alzheimer's disease;
lysosomes;
nanomedicine;
small molecule drugs
- From:
Academic Journal of Naval Medical University
2025;46(4):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is the most common neurodegenerative disease in the elderly,and its main pathological manifestations include senile plaques formed by β-amyloid deposition and neuronal fibrillar nodules formed by hyperphosphorylation of tau proteins.Lysosome is an important organelle in eukaryotic cells,containing a variety of hydrolytic enzymes that can break down proteins and other biomolecules.It is closely related to intracellular transport and autophagy,and is important for maintaining cellular homeostasis.This review summarizes the interaction between lysosomal dysfunction and the development and progression of AD and the potential therapeutic mechanisms in treating AD by regulating and restoring the functions of lysosomes.Lysosomal dysfunction can lead to neurodegenerative diseases such as AD.Modulation of lysosomal function is a promising treatment strategy for AD.It is expected that more drugs and therapeutic regimens based on this mechanism can be used in the clinical treatment for AD patients in the future.
