M2 macrophage metabolism reprogramming in treating sepsis:research progress
10.16781/j.CN31-2187/R.20240465
- VernacularTitle:M2巨噬细胞代谢重编程在脓毒症治疗的研究进展
- Author:
Jinhui YANG
1
;
Zhengyu JIANG
;
Bin LI
;
Jiahao LIU
;
Jinjun BIAN
Author Information
1. 海军军医大学(第二军医大学)第一附属医院麻醉学部,上海 200433
- Keywords:
M2 macrophages;
sepsis;
metabolism reprogramming;
polarization
- From:
Academic Journal of Naval Medical University
2025;46(4):511-517
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis refers to a life-threatening organ dysfunction caused by a dysregulated host response to infection,with persistently high morbidity and mortality,posing a significant healthcare burden.As integral components of innate and adaptive immunity,macrophages exhibit high plasticity and can differentiate into distinct phenotypes(M1 pro-inflammatory and M2 anti-inflammatory)in response to various environmental stimuli,playing crucial roles in both the hyperinflammatory phase and late immunosuppressive phase of sepsis.The metabolic profile of M2 macrophages has gradually become a research focus,and it is regulated by a variety of enzymes and signaling pathways,including adenosine 5'-monophosphate-activated protein kinase,peroxisome proliferator-activated receptor and protein kinase RNA-like ER kinase pathways.These pivotal signaling pathways and enzymes can promote the polarization of M2 macrophages and enhance their anti-inflammatory functions by modulating the metabolism of glucose,lipid,and amino acid,thereby conferring protective effects against sepsis and providing new ideas for the targeted treatment.
