Signaling pathways related to primary blast lung injury:research progress
10.16781/j.CN31-2187/R.20220452
- VernacularTitle:原发性肺冲击伤相关信号通路研究进展
- Author:
Songyun ZHAO
1
;
Chaoyue DIAO
;
Chong BAI
Author Information
1. 海军军医大学(第二军医大学)第一附属医院呼吸与危重症医学科,上海 200433;中国人民解放军南部战区海军第二医院内一科,三亚 572000
- Keywords:
blast injury;
lung injury;
signaling pathway;
phosphatidylinositol 3-kinases;
nuclear factor κB;
mitogen-activated protein kinase
- From:
Academic Journal of Naval Medical University
2025;46(3):406-410
- CountryChina
- Language:Chinese
-
Abstract:
Primary blast lung injury is an acute lung injury caused by the direct impact of explosive shock wave acting on the lung;the serious case can develop acute respiratory distress syndrome,which is one of the leading causes of mortality in blast injury personnel.The pathophysiological characteristics of primary lung blast injury are relatively clear:rupture of the alveolar capillaries and subsequent intrapulmonary haemorrhage and edema,accompanied by oxidative stress,apoptosis,inflammatory reaction and other physiological processes.However,the molecular mechanism needs to be further studied.This paper focuses on the research progress of phosphatidylinositol 3-kinase/protein kinase,nuclear factor κB,mitogen-activated protein kinase and other signaling pathways in the research of primary blast lung injury.
