Predictive value of inflammatory markers for paroxysmal sympathetic hyperactivity after traumatic brain injury:a single-center retrospective case-control study
10.16781/j.CN31-2187/R.20240607
- VernacularTitle:炎症指标对创伤性脑损伤后阵发性交感神经亢进的预测价值:单中心回顾性病例对照研究
- Author:
Hantong SHI
1
;
Wen CHEN
;
Yangu GUO
;
Xianzheng SANG
;
Danfeng ZHANG
;
Lijun HOU
Author Information
1. 海军军医大学(第二军医大学)第二附属医院神经外科,上海 200003
- Keywords:
traumatic brain injuries;
paroxysmal sympathetic hyperactivity;
neutrophils;
neutrophil to lymphocyte ratio;
systemic immune-inflammation index
- From:
Academic Journal of Naval Medical University
2025;46(3):330-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of inflammatory markers in predicting paroxysmal sympathetic hyperactivity(PSH)after traumatic brain injury(TBI).Methods A total of 84 TBI patients who were admitted to The Second Affiliated Hospital of Naval Medical University(Second Military Medical University)from Dec.2016 to Nov.2020 were retrospectively analyzed.They were classified into PSH group(n=41)and non-PSH group(n=43)according to whether PSH occurred during hospitalization.The baseline data and laboratory results of the 2 groups were collected and compared.Kendall correlation analysis was used to analyze the correlation between inflammatory markers and the occurrence of PSH after TBI,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of inflammatory markers to PSH.Results There were no significant differences in baseline data,including age,gender,or Glasgow coma scale score,between the 2 groups(all P＞0.05).Compared with patients in the non-PSH group,the neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),systemic immune-inflammation index(SII),neutrophils and leukocytes in the PSH group were significantly increased(all P＜0.05).NLR,SII and neutrophil were positively correlated with PSH(r=0.360,0.308,0.289;all P＜0.01),with the corresponding ROC area under curve values being 0.752,0.716 and 0.702,respectively.Conclusion NLR,SII and neutrophils have a value in predicting the occurrence of PSH after TBI.
