Role of mesenchymal stem cells in pathogenesis of adolescent idiopathic scoliosis:research progress
10.16781/j.CN31-2187/R.20240041
- VernacularTitle:间充质干细胞在青少年特发性脊柱侧凸发病机制中的作用研究进展
- Author:
Zixiang DENG
1
;
Songzhi NI
;
Xuan LIU
;
Ming LI
;
Yushu BAI
Author Information
1. 海军军医大学(第二军医大学)第一附属医院脊柱外科,上海 200433
- Keywords:
mesenchymal stem cells;
adolescent idiopathic scoliosis;
pathogenesis;
bone metabolism
- From:
Academic Journal of Naval Medical University
2025;46(3):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Adolescent idiopathic scoliosis(AIS)is a complex spinal deformity that occurs in adolescents aged 10-18 years.It is more common in female adolescents.Despite extensive research,the precise pathological mechanisms underlying AIS are yet to be fully elucidated.Given its links to abnormal bone growth and reduced bone mineral density,the involvement of mesenchymal stem cells(MSCs)in bone metabolic disorders is considered a plausible contributing factor of AIS.This review summarizes the role of MSCs in the pathogenesis of AIS and provides a forward-looking perspective on the potential clinical application.
