Autophagy in traumatic brain injury:research progress
10.16781/j.CN31-2187/R.20240116
- VernacularTitle:自噬在创伤性脑损伤中的研究进展
- Author:
Hantong SHI
1
;
Chengqing WANG
;
Yangu GUO
;
Yichao YE
;
Danfeng ZHANG
;
Lijun HOU
Author Information
1. 海军军医大学(第二军医大学)第二附属医院神经外科,上海 200003
- Keywords:
traumatic brain injury;
autophagy;
autophagic flux;
mitophagy;
ferritinophagy
- From:
Academic Journal of Naval Medical University
2025;46(1):111-117
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic brain injury(TBI)is mostly caused by motor vehicle traffic accidents or competitive sports,with high mortality and disability.TBI mainly includes primary injury and secondary injury.Primary injuries were caused directly by external forces.Secondary injuries include brain edema,excitotoxic effect of neuron cells,oxidative stress and neuroinflammation,etc.Effective intervention of secondary injury not only helps to improve the prognosis of patients with TBI,but also reduces the risk of Parkinson's disease and other neurodegenerative diseases related to TBI.Autophagy is one of approaches to regulate homeostasis in cells,and autophagy dysfunction has been found in several neurodegenerative diseases and TBI.It is speculated that autophagy dysfunction may play an important role in TBI and explain why patients with TBI have higher risk of neurodegenerative disease.Discovering the role of autophagy in the pathological mechanism of TBI may provide new targets for TBI clinical treatment and cognitive impairment prevention in patients with TBI.
