NTRK gene fusion in thyroid cancer:an advance
10.16781/j.CN31-2187/R.20240256
- VernacularTitle:甲状腺癌中NTRK基因融合的研究进展
- Author:
Wenyan DONG
1
;
Dezheng SUN
;
Min FANG
;
Yuan SHENG
Author Information
1. 海军军医大学(第二军医大学)第一附属医院甲乳外科,上海 200433
- Keywords:
thyroid neoplasms;
neurotrophic receptor tyrosine kinase;
gene fusion;
targeted therapy
- From:
Academic Journal of Naval Medical University
2025;46(1):103-110
- CountryChina
- Language:Chinese
-
Abstract:
Neurotrophic receptor tyrosine kinase(NTRK)gene fusions are oncogenic drivers in multiple solid tumors,and they are also important clinical biomarkers.NTRK fusion-positive thyroid cancer(TC)exhibits distinctive clinicopathological features.Patients with advanced,metastatic,or iodine-refractory TC should receive evaluation of NTRK fusion status.However,there have been no authoritative recommendations or standardized procedures for the diagnosis and treatment of NTRK fusions in TC.This review discusses the research advances regarding NTRK fusion-positive TC,summarizes the clinicopathological features of the disease,and outlines the current statuses of NTRK fusion detection and targeted therapeutic agents.
