Research progress on molecular mechanisms and nutritional strategies of insulin resistance in children and adolescents
10.16151/j.1007-810x.2025.05.009
- VernacularTitle:儿童青少年胰岛素抵抗的分子机制及营养策略的研究进展
- Author:
Xiao-Na XIA
1
;
Chang-Wei LIU
Author Information
1. 南京医科大学附属儿童医院临床营养科,江苏 南京 210008
- Keywords:
Insulin resistance;
Children and adolescents;
Obesity;
Mechanism;
Nutritional strategies
- From:
Parenteral & Enteral Nutrition
2025;32(5):310-316,320
- CountryChina
- Language:Chinese
-
Abstract:
Childhood obesity and related diseases have become major global public health concerns.Among the underlying mechanisms,insulin resistance has garnered considerable attention as a pivotal factor in the development and progression of childhood obesity.Obesity-related insulin resistance represents a complex physiological and pathological process involving the combined effects of multiple factors.This article reviews the role of insulin resistance in the pathogenesis of childhood obesity,with particular emphasis on the contributions of chronic inflammation,endoplasmic reticulum stress,mitochondrial dysfunction,and Toll-like receptors signaling.In addition,nutritional strategies and exercise interventions targeting insulin resistance are discussed,along with current research gaps and future directions.These research advances may enhance our understanding of the intricate relationship between childhood obesity and insulin resistance,ultimately providing new perspectives and strategies for the prevention and treatment of childhood obesity-related diseases.
