Effect of preoperative intestinal prehabilitation on the recovery of delayed postoperative ileus in sarcopenic gastric cancer patients
10.16151/j.1007-810x.2025.05.004
- VernacularTitle:术前肠道预康复对肌少症胃癌病人术后延迟性肠麻痹恢复的影响
- Author:
Jian-Jun WU
1
;
Guo-Zhong YAO
;
Chu-Ming ZHU
;
Jiang YAN
;
Yu SHEN
;
Shai-Di TANG
;
Die WU
Author Information
1. 溧阳市人民医院普通外科,江苏溧阳 213300
- Keywords:
Intestinal microbiota;
Low skeletal muscle index;
Prolonged postoperative ileus;
Gastric cancer
- From:
Parenteral & Enteral Nutrition
2025;32(5):283-287,292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects and underlying mechanisms of preoperative intestinal microbiota modulation on the recovery of prolonged postoperative ileus(PPOI)in gastric cancer patients with sarcopenia Methods:Skeletal muscle mass(SMM)was assessed using bioelectrical impedance analysis(BIA),and the skeletal muscle index(SMI)was calculated.A total of 156 gastric cancer patients with sarcopenia who underwent surgery at the Department of Gastrointestinal Surgery,Liyang People's Hospital,from January 2022 to December 2024 were randomly assigned to either the control group or the experimental group.The control group received conventional prehabilitation interventions,including nutritional support,respiratory function training,and physical exercise.The experimental group received probiotic-based intestinal microbiota modulation in addition to conventional prehabilitation interventions.Postoperative recovery indicators,including time to first flatus,incidence of postoperative complications,length of hospital stay,and hospitalization costs,were compared between the two groups.Results:Among the 156 sarcopenic gastric cancer patients,121 were male,and 35 were female.Statistically significant differences were observed between the two groups in terms of time to first flatus,incidence of postoperative complications,and length of hospital stay(P<0.05).Postoperative complications occurred in 38 patients(24.3%),with 10 cases(6.4%)in the experimental group and 28 cases(17.9%)in the control group.The time to first flatus in the experimental group was significantly shorter than in the control group(48.0 hours vs 72.0 hours,P<0.001).Conclusion:Preoperative intestinal microbiota modulation significantly reduces the incidence of PPOI and postoperative complications in gastric cancer patients with low SMI,thereby promoting postoperative gastrointestinal function recovery.
