Association of serum ω-6 polyunsaturated fatty acids with fat and skeletal muscle mass indices:a mediation analysis of the systemic immune-inflammation index
10.16151/j.1007-810x.2025.05.001
- VernacularTitle:血清ω-6多不饱和脂肪酸与脂肪和骨骼肌质量指数的关联:系统性免疫炎症指数的中介作用分析
- Author:
Dan ZHANG
1
;
Si WU
;
Wei ZHANG
Author Information
1. 南通大学杏林学院,江苏 南通 226236
- Keywords:
ω-6 polyunsaturated fatty acids;
Systemic immune-inflammation index;
Fat mass index;
Skeletal muscle index;
Mediation analysis;
Restricted cubic splines;
National Health and Nutrition Examination Survey
- From:
Parenteral & Enteral Nutrition
2025;32(5):257-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of serum ω-6 polyunsaturated fatty acids(ω-6 PUFAs)with fat mass index(FMI)and skeletal muscle mass index(SMI),and to assess the mediating role of the Systemic Immune-Inflammation Index(SII)in these associations.Methods:This cross-sectional study was based on data from 1210 adults from the 2011～2014 cycle of the National Health and Nutrition Examination Survey(NHANES).Serum fatty acids were measured using gas chromatography-mass spectrometry(GC-MS),and body composition(FMI and SMI)was assessed by dual-energy X-ray absorptiometry(DXA).The SII was calculated from peripheral complete blood counts.Statistical methods included multiple linear regression,restricted cubic spline(RCS)models,and Bootstrap-based mediation analysis to examine the associations of ω-6 PUFAs with FMI/SMI and the mediating role of SII.Results:Mediation analysis revealed a significant positive association between serum ω-6 PUFA levels and FMI(total effect β=0.000234,P<0.01 in the fully adjusted model).SII partially mediated this association,with the proportion mediated being 16.9%and 15.9%in the crude and fully adjusted models,respectively(P<0.05).For SMI,the proportion mediated by SII was 3%in the crude model and 12.4%in the fully adjusted model,but this did not reach statistical significance(P=0.058).Furthermore,SII had no significant mediating effect on the associations of the serum ω-6/ω-3 ratio or ω-3 PUFAs with either FMI or SMI(P>0.05).Conclusion:Elevated serum ω-6 PUFA levels are associated with increased fat mass,and this association is partially mediated through a systemic inflammatory pathway.The association between ω-6 PUFAs and skeletal muscle mass is primarily a direct effect,as the mediating role of systemic inflammation is not significant.
