Predictive value of platelet parameters and prognostic nutritional index in activity of ulcerative colitis
10.16151/j.1007-810x.2025.04.005
- VernacularTitle:血小板参数和预后营养指数在溃疡性结肠炎活动度中的预测价值
- Author:
Han-Li TAO
1
;
Shu WANG
;
Kang LIU
;
Qin ZOU
;
Wei GONG
;
Feng LI
Author Information
1. 湖南中医药大学第一附属医院肛肠科,湖南 长沙 410007
- Keywords:
Neutrophil platelet ratio;
Prognostic nutritional index;
Ulcerative colitis;
Mayo Total Score;
Clinical activity level;
Endoscopic mobility
- From:
Parenteral & Enteral Nutrition
2025;32(4):223-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the predictive value of platelet parameters and prognostic nutritional index(PNI)in activity of ulcerative colitis(UC).Methods:This retrospective study included 158 UC patients from the Department of anorectal medicine of our hospital from January 2020 to June 2022.Mayo total score and Truelove-Witts score were used to evaluate clinical activity.Patients with Mayo score>2 was defined as clinically active UC,and patients with Mayo score≤2 was defined as clinically remission.The histological activity was evaluated by Riley score.Evaluation of endoscopic activity of UC patients by Mayo endoscopic score.Results:Among the 158 patients included in the analysis,111 were in remission phase and the remaining 47 were in clinical active phase.Compared with the remission group,the levels of albumin,lymphocytes,and PNI in the clinically active group reduced significantly(P<0.05),while the levels of CRP,fecal calprotectin,neutrophils,white blood cells,NPR,and NLR increased significantly(P<0.05).Fecal calprotectin,CRP,NPR,NLR were significantly positively correlated with Mayo endoscopic score,Riley score,Truelove Witts score,and Mayo total score(P<0.05),while PNI was significantly negatively correlated with Mayo endoscopic score,Truelove Witts score,and Mayo total score(P<0.05).The ROC curve analysis results showed that fecal calprotectin and NPR had similar performance in predicting clinical activity in UC patients(AUC=0.868,0.850),followed by PNI(AUC=0.770)and NLR(AUC=0.756);Fecal calprotectin had the highest performance in predicting endoscopic activity in UC patients(AUC=0.840),followed by NPR(AUC=0.731),NLR(AUC=0.677),and PNI(AUC=0.671).Conclusions:NPR has demonstrated sufficient diagnostic utility in identifying UC patients with clinical and endoscopic activity,and is comparable in diagnostic performance to the fecal biomarker calprotectin.However,PNI has lower performance as a monitoring tool for UC disease activity.
