Correlation analysis of urea/creatinine ratio and poor prognosis of sepsis patients with acute respiratory failure:an analysis based on MIMIC-Ⅳ database
10.16151/j.1007-810x.2025.04.003
- VernacularTitle:尿素/肌酐比值与脓毒症合并急性呼吸衰竭病人不良预后的相关性分析:基于MIMIC-Ⅳ数据库
- Author:
Xin CHEN
1
;
Xin-Ying WANG
Author Information
1. 南京大学医学院附属金陵医院/东部战区总医院 普通外科,江苏 南京 210002
- Keywords:
Sepsis;
Acute respiratory failure;
Urea/creatinine ratio;
Correlation analysis
- From:
Parenteral & Enteral Nutrition
2025;32(4):208-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between urea/creatinine ratio and poor prognosis of sepsis patients with acute respiratory failure.Methods:We enrolled sepsis patients with acute respiratory failure in the Medical Information Mart for Intensive Care Ⅳ(MIMIC-Ⅳ).Demographic characteristics,laboratory parameters within the first 24 hours after ICU admission,comorbidities,arterial blood gas analysis,therapeutic managements strategies and disease severity scores were recorded.Patients were categorized based on the quartiles of UCR.The primary outcome was 90-day mortality.Baseline clinical characteristics and patient outcomes were compared across groups.Subsequently,Multivariable logistic regression analysis and restricted cubic spline models were employed to explore the association between UCR and prognosis in sepsis patients with acute respiratory failure.Results:A total of 4 476 patients were included,and patients with high UCR had higher in-hospital,28day,60-day and 90-day mortality as compared to the other subgroups(P<0.001).Through variable selection selected by Boruta algorithm and random forest,we constructed logistic regression model and found that U3 and U4 group were associated with a significantly higher risk of 90-day mortality(OR=1.311,95%CI:1.065～1.614,P=0.011;OR=1.745,95%CI:1.412～2.157,P<0.001).Restricted cubic spline analysis demonstrated a linear positive correlation between UCR and in-hospital,28-day,60-day and 90-day mortality.Conclusions:Elevated UCR level was associated with a significantly higher mortality in sepsis with acute respiratory failure.
