Association between GLIM-diagnosed malnutrition and postoperative adverse outcomes in surgical patients:a systematic review and meta-analysis
10.16151/j.1007-810x.2025.03.006
- VernacularTitle:GLIM标准诊断的营养不良与外科手术病人术后不良结局的关联:一项系统评价与Meta分析
- Author:
Jia-Wei SHI
1
;
Hong-Shuang CHEN
;
Ling-Yu LI
;
Hai-Ou ZOU
Author Information
1. 中国医学科学院北京协和医学院护理学院,北京 100144
- Keywords:
Nutritional assessment;
Global leadership initiative on malnutrition(GLIM)criteria;
Surgery;
Systematic evaluation;
Meta-analysis;
Cohort study
- From:
Parenteral & Enteral Nutrition
2025;32(3):155-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to examine the association between malnutrition diagnosed by the Global Leadership Initiative on Malnutrition(GLIM)criteria and clinical outcomes in surgical patients,as well as to assess its prognostic impact on postoperative adverse clinical outcomes.Methods:Electronic databases,including PubMed,Embase,Web of Science,CINAHL,Scopus,The Cochrane Library,Clinical Trials,CNKI,Wanfang Data Knowledge Service Platform,and the Chinese Biomedical Literature Database,were systematically searched.Relevant cohort studies utilizing GLIM criteria to preoperatively diagnose malnutrition in surgical inpatients were included.The exposed group comprised surgical patients diagnosed with preoperative malnutrition using GLIM criteria,while the control group consisted of surgically treated patients without malnutrition as per GLIM criteria.Literature quality was evaluated using the Newcastle-Ottawa Scale(NOS),and meta-analysis was performed using Review Manager 5.4 software.Results:Fourteen literatures were included,with a total sample size of 10,045 patients.Meta-analysis revealed that the malnourished group had a higher incidence of postoperative complications compared to the non-malnourished group[risk ratio(RR)=1.81,95%CI:1.66～1.98),P<0.00001].Additionally,the incidence of severe complications was significantly higher in GLIM-diagnosed malnourished patients.The malnourished group exhibited poorer overall survival[hazard ratio(HR)=1.90,95%CI:1.55～2.34,P<0.00001]and disease-free survival[HR=2.25,95%CI:1.02～4.93,P=0.04]compared to the non-malnourished group.Conclusion:GLIM-diagnosed malnutrition is significantly associated with adverse clinical outcomes in surgical patients,increasing postoperative complication rates and reducing overall and disease-free survival.The GLIM criteria demonstrate value in predicting adverse clinical outcomes in this population.Further high-quality studies are warranted to validate these findings.
