The effect of glutamine-enriched parenteral nutrition on short-term outcomes after surgery in patients with colorectal cancer
10.16151/j.1007-810x.2025.01.002
- VernacularTitle:谷氨酰胺强化的肠外营养对结直肠癌病人术后短期临床结局的影响
- Author:
Ji-Wei WANG
1
;
Yong HUANG
;
Tao ZHANG
;
Mai-Jian WANG
;
Xin-Bin ZHENG
;
Ming XIE
Author Information
1. 遵义医科大学附属医院消化病医院普通外科,贵州遵义 563000
- Keywords:
Glutamine;
Parenteral nutrition;
Colorectal cancer;
Postoperative complications;
Immune function
- From:
Parenteral & Enteral Nutrition
2025;32(1):7-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of glutamine-enriched parenteral nutrition on short-term postoperative outcomes compared with conventional nutritional support in colorectal cancer patients with enteral nutrition intolerance after surgery.Method:A retrospective cohort study was conducted to collect clinical data from colorectal cancer patients who underwent radical resection at the Department of Gastrointestinal Surgery of Zunyi Medical University Affiliated Hospital from January 2019 to December 2021.The differences in postoperative complication rates,perioperative nutritional indicators,and inflammatory factors between the two groups were analyzed.SPSS 29.0 software was used for statistical analysis.Result:Based on whether glutamine was added to parenteral nutrition,178 patients were divided into a control group(conventional nutritional therapy,n=120)and an observation group(glutamine enhanced nutritional therapy,n=58).The incidence of postoperative complications(Clavien Dindo grade≥III)in the control and observation groups was 14.17%(17/120)and 3.45%(2/58),respectively,with a statistically significant difference(P=0.030).The observation group recovered faster than the control group in terms of time to first expectoration,defecation and intake of liquid diet after surgery,and had a shorter hospital stay after surgery(P<0.05).However,there was no significant difference in the 30-day readmission rate between the two groups(P=0.393).There was no statistically significant difference in the changes in total protein,albumin,pre-albumin,neutrophil/lymphocyte ratio and endogenous creatinine clearance rate between the two groups of patients after surgery(P>0.05).There were also significant differences in the changes in lymphocyte count,white blood cell count,neutrophil percentage,alanine aminotransferase,aspartate aminotransferase,total bilirubin,and urea nitrogen levels between the two groups of patients after surgery(P<0.05).Conclusion:Compared with regular nutritional support,postoperative parenteral glutamine supplementation can reduce the incidence of postoperative complications in colorectal cancer patients,promote recovery of bowel function,shorten postoperative hospital stay,improve patient immune function and reduce inflammatory levels.
