Research progress on the role of neuroinflammation in the occurrence and development of autism spectrum disorder
10.3969/j.issn.1671-8348.2025.11.034
- VernacularTitle:神经炎症在孤独症谱系障碍发生、发展中作用的研究进展
- Author:
Hujing DENG
1
;
Jie TIAN
;
Jiaowei GU
Author Information
1. 湖北医药学院第一临床学院,湖北 十堰 442000;湖北医药学院儿童疾病研究所,湖北 十堰 442000
- Keywords:
autism spectrum disorders;
neuroinflammation;
microglia;
cytokine;
immune modulation
- From:
Chongqing Medicine
2025;54(11):2675-2679,2685
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorders(ASD)are a neurodevelopmental disorder that emerges in early childhood,characterized by impairments in social interaction and communication,repetitive and stereotyped behaviors,and restricted interests.The prevalence of ASD has been increasing,imposing significant burdens on the mental and physical health of affected children,their families,and society.While the pathogenesis of ASD remains unclear,the role of neuroinflammation in its development has garnered increasing attention.Numer-ous studies have indicated that ASD is closely associated with a chronic inflammatory condition of the central nervous system.Findings such as microglial activation in brain tissue of ASD animal models and alterations in levels of inflammatory cytokines,including IL-1 and IL-6,are closely associated with the onset and progression of ASD.This review examines the relationship between neuroinflammation and ASD,to provide insights for a deeper understanding of the pathophysiological processes of ASD and for exploring new clinical intervention strategies.
