Clinical,ultrasound,and pathological characteristics analysis of 37 patients with FAVA
10.3969/j.issn.1671-8348.2025.11.027
- VernacularTitle:37例法瓦病患者的临床、超声及病理学特征分析
- Author:
Wenjiao XU
1
;
Peipei SUN
;
Huaiqing HE
;
Xin JIN
;
Baomin LIU
Author Information
1. 西安国际医学中心医院超声诊疗二科,西安 710000
- Keywords:
FAVA;
clinical manifestations;
ultrasonographic features;
pathological characteristics
- From:
Chongqing Medicine
2025;54(11):2638-2642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and summarize the clinical manifestations,ultrasound images,and pathological features of the rare disease fibro-adipose vascular anomaly(FAVA),in order to improve under-standing of the disease and reduce misdiagnosis rates.Methods The clinical manifestations,lesion locations,ultrasound images,and pathological findings of 37 patients diagnosed with FAVA in this hospital from January 2023 to December 2024 were analyzed.Results FAVA predominantly occurred in children and young and middle-aged women,mainly presenting as hard masses in the calves,progressive pain,with some cases ac-companied by movement disorders.It was rarely seen in the thighs,forearms,upper arms,and elbow joints.The disease primarily affected muscles and rarely affected nerves.When muscles and nerves were involved,it exhibited characteristic ultrasonographic features and unique imaging manifestations on magnetic resonance imaging.In immunohistochemistry,besides vascular and lymphatic markers such as CD31(vascular+),CD34(vascular+),D2-40(lymphatic+),and ERG(vascular endothelial cells+),some lesions also showed molecu-lar markers including Factor Ⅷ(+),Ki-67(<1%+),Vimentin(+),β-catenin(partial+),and SMA(partial+).Conclusion Awareness of the ultrasonographic and pathological characteristics of FAVA should be increased to reduce the misdiagnosis rate.
